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A cancer-specific L-type amino acid transporter 1 (LAT1) is highly expressed in cancer tissues. Inhibiting the function of LAT1 has been known to have anti-tumor effects, but there has been limited progress in the development of radionuclide therapy agents targeting LAT1. Now, a multidisciplinary research team at Osaka U yeezys niversity has established a targeted alpha-therapy with a novel drug targeting LAT1.The researchers first produced the alpha-ray emitter211Astatine, no nike store dunk easy task given that Astatine (At) is the rarest naturally occurring element on Earth. Targeted alpha-therapy selectively delivers 伪-emitters to tumors; the advantage over conventional 尾-therapy is t nike dunk sb hat alpha decay is highly targeted and the high linear energy transfer causes double-strand breaks to DNA, effectively causing cell death. The short half-life and limited tissue penetration of alpha radiation ensures high therapeutic effects with few side-effects to surrounding normal cells.Next, to carry the radioisotope int Maryam Nawa adidas campus z, the daughter of Prime Minister Nawaz Sharif, on Monday served Rs1 adidas campus uomo billion legal notice on PTI information secretary Naeem Ul Haq for accusing her of leaking the news regarding a high-level meeting between the top civil and military leadership.Haq had alleged that Maryam Nawaz was the main character behind the story.The notice read that the accusation has been broadcast on different news campus adidas channels. It said that the accusation against Maryam is defamatory, false, scandalous, mala fide, untrue and without any evidence. Maryam, through her legal notice, asked the PTI leader to tender unconditional apology and withdraw the accusation.Published in The Express Tribune, November 1st , 2016.
A cancer-specific L-type amino acid transporter 1 (LAT1) is highly expressed in cancer tissues. Inhibiting the function of LAT1 has been known to have anti-tumor effects, but there has been limited progress in the development of radionuclide therapy agents targeting LAT1. Now, a multidisciplinary research team at Osaka U yeezys niversity has established a targeted alpha-therapy with a novel drug targeting LAT1.The researchers first produced the alpha-ray emitter211Astatine, no nike store dunk easy task given that Astatine (At) is the rarest naturally occurring element on Earth. Targeted alpha-therapy selectively delivers 伪-emitters to tumors; the advantage over conventional 尾-therapy is t nike dunk sb hat alpha decay is highly targeted and the high linear energy transfer causes double-strand breaks to DNA, effectively causing cell death. The short half-life and limited tissue penetration of alpha radiation ensures high therapeutic effects with few side-effects to surrounding normal cells.Next, to carry the radioisotope int Maryam Nawa adidas campus z, the daughter of Prime Minister Nawaz Sharif, on Monday served Rs1 adidas campus uomo billion legal notice on PTI information secretary Naeem Ul Haq for accusing her of leaking the news regarding a high-level meeting between the top civil and military leadership.Haq had alleged that Maryam Nawaz was the main character behind the story.The notice read that the accusation has been broadcast on different news campus adidas channels. It said that the accusation against Maryam is defamatory, false, scandalous, mala fide, untrue and without any evidence. Maryam, through her legal notice, asked the PTI leader to tender unconditional apology and withdraw the accusation.Published in The Express Tribune, November 1st , 2016.
